Cardiac sympathetic denervation supersensitivity in Parkinson's disease
نویسندگان
چکیده
منابع مشابه
Modulation of drug effects by regional sympathetic denervation and supersensitivity.
BACKGROUND Regional sympathetic denervation, such as that produced by a myocardial infarction, causes electrophysiological heterogeneity in the ventricles. The purpose of this study was to test the hypothesis that such denervation could cause drugs to exert heterogeneous myocardial effects. METHODS AND RESULTS Sympathetic stimulation increases the amplitude of cesium chloride-induced early af...
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The pathophysiology of heart failure (HF) has long been linked to a neurohormonal imbalance because of excessive compensatory activation of the sympathetic nervous system (SNS). As HF develops, cardiac function is progressively lost prompting an increase in SNS activity in an attempt to maintain homeostasis and stabilize cardiac output. Although initially providing beneficial ionotropic support...
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To determine whether the chronically denervated kidney is supersensitive to either physiological or pathophysiological plasma levels of norepinephrine (NE), studies were conducted in conscious dogs subjected to unilateral renal denervation and surgical division of the urinary bladder into hemibladders to allow separate 24-h urine collection from denervated and innervated kidneys. Plasma NE conc...
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BACKGROUND Transmyocardial laser revascularization (TMR) has been shown to improve refractory angina not amenable to conventional coronary interventions. However, the mechanism of action remains controversial, because improved myocardial perfusion has not been consistently demonstrated. We hypothesized that TMR relieves angina by causing myocardial sympathetic denervation. METHODS AND RESULTS...
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Cardiovascular responses to intravenous administration of norepinephrine and the properties of alpha receptors on platelets were compared in normal human subjects and subjects with multiple system atrophy (MSA) and sympathetic degeneration. All the subjects with MSA had low plasma norepinephrine concentrations (in the supine position) (0.42 +/- 0.09 nM, normal 3.47 +/- 0.58 nM), which did not i...
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ژورنال
عنوان ژورنال: Journal of the Japanese Society of Intensive Care Medicine
سال: 2015
ISSN: 1340-7988,1882-966X
DOI: 10.3918/jsicm.22.12